Understanding Native American History

American history is filled with glorious accomplishments that Americans love to point out when saying how great a country this is. Certainly, America is a great country, and as countries go, it has probably done enough now to forever remain as one of the great countries ever to exist on the planet. Perhaps it will someday go down in history beside Ancient Rome, Ancient Egypt, Ancient Greece and other great civilizations of the past that have made their mark on human history, but along with its greatness, America has enough faults and shame to give pause for thought. In a country of immigrants, America has historically mistreated its immigrants, especially the Chinese, the Japanese and today the Chicanos. Despite their efforts to get away from religious persecution, the pilgrims were not so eager to avoid religiously persecuting others and forcing their religion upon everyone. Everyone is keenly aware of how America enslaved the blacks and then held them down as second class citizens or less after slavery was more or less begrudgingly abolished. Black Americans were not properly treated in American until the 1970s and even today blacks suffer from the vestiges of past slavery. Yet, with all of the two-sided treatment and mistreatment of so many cultures that have today merged within the amalgamated American culture, with all of the irony and tragedy of those mergers, perhaps none is any more tragic than that of the American Indian.   With all the Native Americans who lived in this country when Europeans arrived, today there are only an estimated 2.75 million remaining.   They are probably the only ethnic group whose numbers in America have fallen since the arrival of Europeans. While the number of Native Americans in the country when Europeans arrived is speculative, it is estimated that there were between 60 and 100 million Natives here when Europeans arrived and that by 1650, the Native population had already decreased by 90 percent due largely to the introduction of European diseases into the Native populations. (MacCleery, 2004) While Black Americans have more or less assimilated into American society despite the mistreatment they suffered, nothing could be further from the truth for Native Americans.   Blacks can be found in large numbers all over the country with few exceptions other than the northwest where there are still areas where people have never seen blacks or rarely do, yet one would be hard pressed to find a Native American in the US away from the reservation. When encountered, they would usually be mistaken for something other than a Native American and always, always they will be speaking a foreign language, usually English, Spanish or both. Forced to abandon their native language, many young Indians today cannot speak their native language and others won't speak it expect to other Natives, and while blacks can occasionally be heard asking for â€Å"reparations† for the wrongs that were committed against them during slavery (those who were wronged are dead) such that their ancestors (those now alive) get to reap the benefits for the suffering of their ancestors, nobody is available to speak up for the Native American who still suffers today in ways that blacks and other ethnic groups do not. Certainly, blacks no longer have their native tongue, but it was not forced out of them in the same way and there was no effort to Americanize blacks.   To the contrary, blacks were maintained separate while the effort towards natives was more like the extermination of the Jews in Nazi Germany.   Whites on the Plains sometimes killed Indians just because they were Indian somewhat like the extermination of the aborigines in Tasmania who were actually, literally hunted down to extinction! Between 1803 and 1833 the Aboriginal population of Tasmania went from 5,000 to around 300 and by early in the 20th century they became virtually extinct, their original languages lost.   Native Americans were intentionally subjected to a similar fate and today their languages are also being lost, this despite the fact that the language of the Navajo code talkers took part in every assault the U.S. assault in the Pacific war against the Japanese from 1942 until 1945. The very languages which helped to save America were not allowed to be spoken among the Natives!   What right do blacks and others have for reparations for what their ancestors suffered when Native Americans are still living basically on reservations in the 21st Century and get virtually nothing? There is no doubt that the survival of the first Europeans to America was due in large part to the ability of the native peoples already here to survive and thrive in this country—in their own land. Even today, each year we celebrate Thanksgiving because we realize that the new visitors to this country owed their survival and existence to the knowledge and ingenuity of the native peoples who were already here. Yet, most Americans today fail to realize the true diversity of the native peoples who already existed here when Europeans arrived. It is estimated that humans lived in North America up to 12,000 years ago and perhaps as much as 40,000 years ago certainly calling into question Bible stories of Adam and Eve a mere 6,000 years in the past. When Europeans arrived, the Native Americans were a vast diversity of cultures, nations and religions that ranged from one coast to the other, people living together in harmony with their environment and with their fellow Native Americans at times, living very much out of harmony with their fellow Native Americans at others.   As was true in Europe, all was not always calm and peaceful co-existence between the various a sundry â€Å"races† and tribes of the Native countries. Native nations differed in terms of their religious beliefs, cultural habits, dietary habits, migratory habits, religions and more, sometimes bringing them at odds with one another, especially in terms of competition for food and perhaps at times for living space. The American mistreatment of the Native peoples they found here began even before the Revolutionary war.   The very natives who saved the lives of the first colonists and pilgrims were treated like second class citizens or not as citizens at all.   By the time of the Revolutionary War, Native Americans had already felt the encroachment of the white Europeans on native lands.   When over two-hundred Iroquois, Shawnees, Cherokees, Creeks and others visited St. Louis in 1784, they were already feeling displaced. One said, â€Å"The Americans, a great ambitious and numerous than the English, put us out of our lands, forming therein great settlements, extending themselves like a plague of locusts in the territories of the Ohio River which we inhibit.† (Galloway, p. 158)   In May 1830, the Indian Removal Act was passed in Congress. It authorized the president to negotiate treaties to remove all Indian tribes living east of the Mississippi. This led to surveyors, squatters and a campaign of harassment against Natives such as the Cherokee. While the Cherokee Nation brought a suit against the Act, Chief Justice John Marshall declared that the court had no jurisdiction over the case since Cherokees were not U.S. citizens or an independent nation. (Garrison, pp. 1-12)   This is certainly a sad state of affairs for the Native peoples of American, one for which there has never been a true champion and which has great significance for the way in which Native Americans still live today. Early in the 20th Century, Joseph Dixon wrote an aptly named book entitled The Vanishing Race that detailed many of the struggles and travails of the Native American. With all of the struggles and travails of the Native American, it was not until December 8, 1911 that President Taft signed a bill passed by Congress granting a United States Reservation and the erection of a National Indian Memorial (Dixon, p. xx). Dixon speaks of an â€Å"Expedition of Citizenship to all tribes of American Indians†, an effort to extend friendship to all Indians and to have them unite so as â€Å"to raise the same flag and sign the same pledge of loyalty and receive at the hands of his representative an American Flag†¦that they might call their own.† (Dixon, p. xxii), but while at the time, this might have been viewed as a sign of advancement by white America, it was no more than further evidence of the forced assimilation and continued mistreatment of the Native Americans who were being robbed of their land, their customs, their language, their religion and forced to assimilate into and assume the American culture strange to them and certainly not their own. For example, Calloway speaks of how the far ranging Comanche bands came together as a nation in the 1870s after they were confined to a reservation. (pp. 339-40)   These nomadic people became a â€Å"Nation† more or less because they were forced to do so. In the 1870s and continuing through the 20th Century, native Americans in defense of their homeland who had once suffered military attacks (and still did in the 1870s and beyond) from invading Europeans suffered a different king of attack, the efforts to Americanize the Natives, an effort to reform the native â€Å"savages† as they were called by forcing them into the European ways of life.   Indians were relocated, forced to wear European attire, to cut their hair and to speak the European languages. Christian missionaries played a large role in this effort as the missionaries simultaneously tried to convert the â€Å"savages† to Christianity and to Christ.   As reformer Helen Hunt Jackson put it in her 1881 book, A Century of Dishonor, those who believed that the United States should extend their blessings to the Natives could see that what was happening was just the opposite. Natives were being â€Å"(shot)†¦down in the snow.† (p. 335) It was a concerted effort to remake the Natives by transforming them into the image of white America and it was met with resistance by the natives. Natives, many of whom migrated with their food supply, the weather and the seasons, were forced to adapt to and adopt strange, European ways. While Europeans claimed a kinship to the land, that kinship was very different from that of many natives. The idea of owning land seemed strange to the natives, and being tied to a specific region to till the soil as farmers was not the native idea of kinship to the land. As Europeans pushed West in their quest for â€Å"Manifest Destiny,† they progressively displaced the natives by killing their food supplies, searching for yellow iron (gold), stealing the Natives’ horses and more. Chief Joseph said, â€Å"For a short time, we lived quietly. But this could not last†¦The white men told lies for each other. They drove off a great number of our cattle†¦ We had no friend who would plead our cause before the law councils.†   What Chief Joseph saw happening was common all across the new continent—new to Europeans.   After the Civil war, the efforts at Manifest Destiny continued and increased. â€Å"Winning the West† was a national goal that led European settlers to move into native lands in greatly increasing numbers. So, the native peoples were being robbed, displaced, involuntarily acculturated, tied to the land in ways that were very un-native, and more. While Europeans forced natives into one compromise after another, the growing sentiment among the invading Europeans was that Indians should be treated as wards of the government rather than as independent nations. (Galloway, p. 271) Today Indian tribes enjoy the unique political status as sovereign nations within the United States, a status they already enjoyed before the arrival of Europeans. They have managed to regain what they lost at the hands of the Europeans, but only after paying a terrible price and being nearly exterminated and what they have today is only a shadow of what they had in the past. Certainly, Americans are essentially oblivious to the plight of the Native Americans.   There has never been a successful spokesman for them, no eloquent Martin Luther King and Cesar Chavez for the American Natives.   Those who existed in the 19th century were quickly killed, imprisoned or ignored as were the few whites who stood up to champion the cause of the Natives, among them former President Herbert Hoover. Therefore, today, while many Americans are at least vaguely familiar with the plight, suffering, indignity suffered and torture of the African slave, few Americans know the true story of the Native Americans and their suffering, suffering that continues even to the present time.   We need a better understanding of what they have suffered in the past and what they continue to suffer even in the present, how they were dispossessed from their lands, moved elsewhere and basically ignored even to the present. Finding a reasonable way to compensate them will not be easy.   Indeed, compensation is probably impossible.   Who can compensate the Tasmanian peoples now that they have been exterminated?   Likewise, who can compensate the Native Americans not that they have been dispossessed and nearly wiped out?   Their story is one that is seldom told even today and is generally distorted when told.   Can we as Americans continue to live with this situation?   Perhaps we can, but should be?   I believe that the answer to that question is, â€Å"No!† References Dixon, Joseph Kossuth.   The Vanishing Race. The Last Great Indian Council.   Philadelphia, PA: National American Indian Memorial Association Press, 1925. Galloway, Colin.   First Peoples: A Documentary Survey of American Indian History. Boston: Bedford/St. Martin's Press, 2004. Garrison, Tim Alan.   The Legal Ideology of Removal:   The Southern Judiciary and the Sovereignty of Native American Nations.   University of Georgia Press, Athens, GA, 2002, pp. 1-12. Jackson, Helen Hunt.   A Century of Dishonor: A Sketch of the United States Government's Dealings With Some of the Indian Tribes.   New York, NY:   Harper & Brothers, 1885. MacCleery, Doug.   The Role of American Indians in Shaping The North American Landscape, Forest History Society, 2 November, 2004, 12 June, 2007.

Management and Work Culture Essay

Instrumental to conduct SWOT analysis, and 3. Plan and build strategy based on the work culture How to develop strategic and operational plans by knowing work culture It is integral part of any individual, and organization. It describes shared value of an organization. It helps anyone to understand how things are done. Here is my cultural preferences: well resourced, ethical, and teamwork centered. Knowing my ideal work culture, I can do better planning and formulate the strategies for an organization. My cultural preferences Necessary resources to do high standard work. Using advantages of available resources, one can do better job of delivering projects with high quality standards. Active promotion of equal rights and justice for all. It will create a culture to grow with the company attitude. Fairness among the employees and employer makes everyone trust each other and the employer. Emphasis on social and environmental responsibility. In this culture, work and life balance here. Social and environmental responsibility culture will help employees more committed to the employer. Because organization is not just focusing on profit itself but also understand human values and help communities around them. Interdependence. Culture of interdependence makes everyone connected, and emphasis the important of collaboration between them. It results toward high level of performance, innovation, and productivity. Friendly and supportive colleagues. Friendliness and supports among colleagues is highly important for employees to challenge themselves, confront each other, and share the knowledge between them. Essential Competencies to Conducting (SWOT) analysis Strategizing competency is one of the most essential to do SWOT analysis. Steps to conduct SWOT analysis: 1. Identify mission statement and goals, 2. Review of internal strength and weaknesses, and 3. To find external opportunities and threats that affect the business or an organization. How my competencies relate to the essential competencies for conducting a SWOT analysis Based on competencies and career interests profiler, my strength are 1.

Field Observation Report

Field Observation Report of Introduction to Public Speaking On the basis of my ambition to one day become a political figure in the United States government, I was obliged to observe Introduction to Public Speaking, COM 110. Dr. Jason Ingram teaches Introduction to Public Speaking on Tuesdays and Thursdays from 6:00 pm to 7:15 pm in the College of Communications on North Campus.I conducted my observation of COM 110 on September 8 and 10. According to the course syllabus, the main goal of this class is to educate students on the fundamentals of public speaking in order to advance critical reasoning skills and gain the ability to present a well-constructed speech (Ingram, course syllabus). The main concept of my study was to learn how reading, writing, and speaking were entailed in this course’s curriculum.COM 110 dignifies the meaning of effectively communicating a message to a particular audience group as a purpose for creating various types of speeches and strategies. It is e mbedded in the field of communication and the discipline of the social sciences. This course incorporates applications of strategic planning and critical thinking for supporting arguments, the determinants of the rhetorical situation, and audience awareness used to enhance communications skills for use in any public environment.Through the practice of organizing the speech, reading and researching proven techniques and strategies for effectively communicating a message to the audience, and applying concepts in speeches and conducting peer reviews for future benefit, students are able to hone exceptional speaking techniques that they can later resort to in interviews, public forum, or any other oral aspect in their professional career. By taking advantage of the opportunity to observe Dr.Ingram’s class on two separate occasions, through interviewing a undergraduate and the professor himself, and by examining how public speaking impacts various careers, I came to grasp the noti on through an assortment of ways why this course is an exceptional representation of its field and discipline. After a short amount of time observing Dr. Ingram’s class, I came to comprehend how COM 110 helped students develop strong oral and critical thinking skills. This class can generally be classified as mainly a presentation-based class with some occasional lectures focusing on key concepts.The main educational purpose of lecture-based days was to reinforce the content involved in the chapters that were assigned for homework the previous class. Dr. Ingram carried out this theme by having open class discussions on specific material and generalized public speaking topics. He stated in his syllabus that every class was an opportunity for someone to voice their opinions, to actively participate in an effort to create an intellectually stimulating learning environment and to ask questions or request additional information on material that is unclear (Ingram, Course Syllabus) .The professor also encouraged small group work in order to learn the fundamental format of how speeches were traditionally conducted. The two class days that I attended however, focused primarily on presentations. Dr. Ingram commenced class by reviewing the rubric as criteria for which impromptu speeches were based off of. Prior to handing out topics to the students, he encouraged all of them to stand up and babble or recite mostly consonant-based phrases like sally sells sea shells down by the sea shore in an attempt to warm up their mouths for speaking.Once the students were fully capable of projecting their voices he assigned topics accordingly to the people who had signed up to present for that particular day. He allowed them to choose one topic out of three possible categories written on note cards. After the student chose the topic, he or she was given a maximum of eight minutes to prepare for the speech. During this time frame the professor strongly encouraged that the stude nts go into the hallway so that they could carefully formulate a plan to successfully present their impromptu speech to the class.Dr. Ingram also suggested reading the newspaper or other news-based text in order to have an additional source to relate the topic back to. Once the preparation time ceased, the students had three to four minutes to present their topic to the class referring to nothing but a few note cards. Each of the speeches were critiqued by two of their fellow classmates in an effort to relay to the student how they could effectively improve their presentation style for the future.This structure based upon which learning critical thinking and strategic skills are applied to presentations with the addition of receiving feedback from other students allows the presenter to truly build their communication skills. The class objectives of COM 110 are â€Å" to understand elements of the rhetorical situation characterizing public speaking; advance well-supported arguments using sound reasoning and evidence; craft messages for various types of audiences; construct effective feedback for peers and for self-improvement; and understanding some of the persuasive strategies at work in political messages,† (Ingram, Course Syllabus).Dr. Ingram addresses these course goals through an array of methods upon each class meeting. The best technique that he used for carrying out the course objectives was by having the students perform different types of speeches for the rhetorical situation and receiving feedback on their performance. Over the course of the semester the professor plans to have the students present a wide variety of topics through the use of impromptu, informative, persuasive, and call to action based speeches.He encourages that students dress accordingly for their speech so that they are able to place more emphasis on the specific message they are conveying to the audience. Since COM 110 is an introductory-based course, the 23 students in my session were comprised primarily of freshmen and sophomores. The small class size signifies that the learning environment is much more active and participation-based than traditional introductory courses. Most of the students that attended the class were seeking differing majors but needed a communications elective in order to fulfill the General Education Program (GEP) requirement.Since this course was an introductory class, the professor did not require the students to have any prerequisites or prior knowledge of public speaking. Aside from the students majoring in radically different subjects, they all had the common goal of wanting to develop exceptional public speaking skills for their future careers. In addition to conducting a comprehensive observation on COM 110, I had the opportunity to gain insight from a sophomores’ perspective of the class along with how the student planned on utilizing these skills in his future career.In addition to this, I also conducted an int erview with Dr. Jason Ingram to learn how his past experience helps to inform the students about all the intricacies of public speaking. I first interviewed Michael Esposito, who is currently a sophomore in computer programming. When asked about why he originally signed up to take COM 110 he bluntly stated that it was â€Å"a required course in order to graduate with a Bachelor of Science in Electrical Engineering,†(Esposito).After hearing this I was inclined to discover his initial impressions and experiences on the class. He enlightened me by explaining that â€Å"the class seems to be of appropriate difficulty for an introduction class, but is graded more on an artistic basis instead of the effectiveness of each speech,† (Esposito). Based on his personal experience, he felt that in order to meet these expectations a student must first master the task of feeling comfortable in front of the class while simultaneously conveying his or her thoughts in an appealing way.W hen asked what skills he deemed were required to be successful in the class he responded that â€Å"confidence and logical reasoning are the most important traits used in speaking in order to convince the audience that the speaker is not wasting their time,† (Esposito). He emphasized that if the speaker presented a flawless argument or appeared meek in any form that they were deemed unqualified for the speech and deserved to be tuned out by the audience. After hearing this, I was intrigued to find out how exactly he planned to benefit from taking COM 110.He reveled to me that he planned to use this class in order to â€Å"convey his engineering ideas to lawyers, politicians, and administrators without using so much jargon that only another engineer could understand,† (Esposito). He went on to inform me how everyone can benefit from taking COM 110 since the traits acquired from the class are universally sought after by a virtually every employer. Once I had an idea how the students in COM 110 planned to apply their communication skills for their future, I opted to find out how the lecturer honed his past experience to educate the undergraduates about public speaking. I interviewed Dr.Jason Ingram, the instructor of COM 110, who holds an MA and a PhD in communication and is an assistant professor in the College of Communication. In an effort to discover why Professor Ingram teaches his class slightly different from other COM 110 classes, I questioned him about his past experiences in communication. He inherently told me that he has â€Å"been the assistant director of debating and held several debate summer workshops in the past,† (Ingram). To my surprise the focus of his research was largely based off of rhetorical and cultural studies. He focused on how the application of political values affected ommunication through observing works in popular culture with a rhetorical point of view (Ingram). In addition to his past experience, I was inte rested to find out how Dr. Ingram incorporated reading and writing into a communication-based class. He informed me that the reading material assigned for homework built a strong foundation for being able to conduct a speech for the rhetorical situation. He also explained that the only writing assignment aside from constructing speech formats was a topic proposal paper where the student was to use their creativity and perform a speech on a topic that they deemed either interesting or educational.Even though COM 110 stresses the importance of developing critical thinking skills for communication, it is imperative to understand how it is applied to various careers. Any student at NC State can expect to benefit from the skills that one acquires in this class. Regardless of career, public speaking is viewed as a vital component of communication where interaction with the audience is used in order to create a connection (Zarefsky 7). Despite preconceived notions about public speaking bei ng a one way message system, it is quite the contrary.The speakers’ ideas are often tested by interacting with the audience, while the listeners’ knowledge and comprehension of the topic are refined through communication with the speaker (Zarefsky 7). As a result, public speaking is often viewed as a constant communication process where messages and gestures are often exchanged between the speaker and listeners (Zarefsky 7). Taking into account the importance of creating a connection with the audience in the rhetorical situation, one can say that public speaking has unparalleled value in every career.The preconceived notion of COM 110 by every student required to take it at NC State can be insignificant, however, it proves to have intrinsic value. This course not only teaches the fundamentals of public speaking but also represents the field of communication in a variety of manners. Through the use of developing critical thinking skills and applying them to the rhetoric al situation, increasing confidence in speaking in front of an audience, and creating a connection with the audience, students in COM 110 gain vital skills that aid in their quest to mastering all aspects of ommunication. Hence, COM 110 is a brilliant representation of the communication field that provides students with an extraordinary skill set for any career. â€Å"Cited References† Esposito, Michael. E-mail interview. 13 Sept. 2009. Ingram, Jason. Communications 110: Introduction to Public Speaking. Course Syllabus. Fall semester 2009. Ingram, Jason. Personal interview. 10 Sept. 2009. Zarefsky, David. Public Speaking: Strategies for Success. Boston: Pearson Education Inc, 2008.

Meiosis; Asexual and Sexual Reproduction; History of Genetics; Assignment

Meiosis; Asexual and Sexual Reproduction; History of Genetics; - Assignment Example Meiosis The process of meiosis is divided into two segments; Meiosis I and Meiosis II. Meiosis I is similar to mitosis and consists of Prophase I, Metaphase I, Anaphase I and Telophase I. When the first division comes to an end, there is the formation of two daughter cells and each contains 23 chromosomes and has undergone crossing over. Crossing over is the exchange of genetic material between two chromosomes. Meiosis II consists of the same stages. However the end stage produces four daughter cells each having a different genetic make-up. All four cells convert into sperms in males while in females only one matures as egg or ovum. As mentioned earlier, meiosis plays a very important role in sexual reproduction by causing genetic variations in the offspring. It reduces the number of chromosomes in the parent cells which are egg and sperm, collectively called as gametes or sex cells. Because of this reduction each cell contains only one set each. A process of independent assortment takes place where each allele gets different chromosome varying at any specific locus. Secondly, it also allows crossing-over which results in genetic mix-up between the two parental chromosomes and we see genetic variations in the offspring. Asexual and Sexual Reproduction Asexual reproduction is defined as a type of reproduction where the organism produces an exact copy of itself without any genetic variation or involvement of any other individual. Different organisms reproduce asexually in various manners. For instance bacteria reproduce by binary fission and the yeast by budding. Fragmentation, spore formation and vegetative reproduction are some other forms of asexual reproduction. Sexual reproduction, on the other hand, is a process where two parent organisms create an offspring that has a combination of genetic material from both the parents. Most of the animals and plants reproduce sexually. However there are certain organisms that reproduce both sexually and asexually like star fish, sea anemones, slime molds and aphids. Organisms that reproduce asexually can create descendents in large numbers but since the offspring have very few DNA variations they are all equally vulnerable to diseases. However sexually reproducing organisms undergo genetic variations and the species are stronger in withstanding the harsh environment. The sexual organisms also produce lesser amount of offspring. Because of this reason the organisms that reproduce through both ways, switch towards sexual reproduction under unfavorable conditions. This helps them in acquiring the genetic variations that facilitate them in adapting to the surroundings. However sexual reproduction is an energy requiring process in contrast to asexual reproduction which requires minimal amount of energy. To explain the extensive use of sexual reproduction by organisms, George C. Williams used the example of lottery tickets. Sexual reproduction is like buying few tickets of different numbers which increases the chance of winning. While asexual is like buying loads of tickets with same numbers. This theory is not considered now because of newfound evidences. History of Genetics History of genetics can be traced back to 1866 when the work of Gregor Johann Mendel on pea was pu blished and his theory was recognized as Mendelian Inheritance. He was the first to study the genetic inheritance patterns in the peas and the fact that they followed a certain rule. After this breakthrough in the world of genetics different such theories came into sight. One considerable work was done in 1900 by Hugo de Varies, Carl Correns and Erich von Tschermak and was

Analysis of the book Night by Elie Wiesel Essay Example | Topics and Well Written Essays - 750 words

Analysis of the book Night by Elie Wiesel - Essay Example Elie Wiesel is one such survivor, whose post-liberation life would be filled with mental anguish. In his seminal book Night, first published in Yiddish in 1955 and later appeared in English in 1960 we evidence how his faith in God as well as faith in humanity is challenged by the grave circumstances faced in German ethnic cleansing operations. The following passages will analyze how Wiesel’s faith in God and humanity is shaken to the core in the face of compelling circumstances and consequences. In a poignant passage in the poetically assembled book, Wiesel notes how, at one point during the life in the ghetto, taking care of his ailing father becomes burdensome. Already weakened by severe malnutrition and mental disorientation, his mind loses perspective and emotional connection with his father. He simply does not have the resources of empathy and solidarity to be able to care for another human. It makes him lament the forceful encampment that was the beginning of the great long ordeal: â€Å"Never shall I forget those moments which murdered my God and my soul and turned my dreams to dust. Never shall I forget these things, even if I am condemned to live as long as God Himself. Never.† In a tragic turn of events, his father would be beaten to death by German guards, just two weeks before American army liberated his camp. Wiesel could hear the final shrieks of pain from his father from his slot in the upper deck. But he could not venture a thought or an action to mitigate his suffering. Even sacrificing his own life for his once beloved father was beyond him. This is a key passage in Night, for it reveals how the Holocaust had stripped the humanity of the victims as well. The â€Å"loss of humanity† with respect to the Holocaust, is thus, equally witnessed in the perpetrators and the victims of the great crime. Hence, much in contradiction to preaching in the covenant, Wiesel fails to take care of fellows of his community, most notably his father. But Wiesel’s is not the universal case, for there are those exceptional individuals who could must spiritual and physical resources to offer themselves in service to other weaker members of the ghetto. This d ifference in behavior is not a consequence of moral convictions or volitional choices of the ghetto inmates. Rather, they just showcase the manifest act of God through the lives of the faithful. The following passage highlights how the inmates of the ghetto encouraged each other during grave times: â€Å"There's a long road of suffering ahead of you. But don't lose courage. You've already escaped the gravest danger: selection. So now, muster your strength, and don't lose heart. We shall all see the day of liberation. Have faith in life. Above all else, have faith. Drive out despair, and you will keep death away from yourselves. Hell is not for eternity. And now, a prayer - or rather, a piece of advice: let there be comradeship among you. We are all brothers, and we are all suffering the same fate. The same smoke floats over all our heads. Help one another. It is the only way to survive.†Ã‚  (Wiesel, 1960) Elie Wiesel’s was brought up in an orthodox Jewish community tha t gave emphasis to religious observance and faithful understanding of the scriptures. This pre-eminence to God and belief in His benign will would be challenged to the core as Wiesel and other Jews are pushed ever further into the systematized abyss. But, instead of abandoning his faith completely, Wiesel gets new illuminations into his faith. In many ways, the experiences in the ghetto

Identification and Recommendation of Alternative Strategies for Research Paper

Identification and Recommendation of Alternative Strategies for McDonalds - Research Paper Example The fast-food culture is fast expanding into the developing nations, as more and more people are attracted towards the taste, quick service, consistency and cheap prices. Out of the total restaurant revenues of the developed nations, the fast food outlets account for almost half. "It is no longer enough to just fill someone's stomach - you have to do it better and faster than others do. Product innovation, customer satisfaction, and differentiated promotions are of utmost importance - now more than ever" (Shekeb Naim, 2008) The industry has nearly matured in the developed countries but in countries like India, the fast food industry is growing at a rate of over 40% per annum. The growth of the IT and IT enables services in India were the bulk of urban youth are working with big pay packets and little time to cook are driving the growth. Growing concerns over the fat and salt content of some fast foods have led to severe criticism of eating fast food and have prompted the industry to offer an increasing range of "healthy" fast foods. A typical fast food outlet carries high overheads in terms of rents, rates, labor costs and bank interest charges. The market is labor intensive and involves considerable start-up and ongoing capital investment. The fast-food industry has a lot to thank McDonald's for. Especially the supply chain management of this company is highly regarded as one of the best in any industry and fast food companies try to emulate the McDonald way of operations.

Position Paper 2 Essay Example | Topics and Well Written Essays - 250 words

Position Paper 2 - Essay Example Therefore, it keeps friends and relatives abreast of the happenings in college through the same. The classroom is an area in which social media has a significant impact besides being the core of the higher education experience. According to Kist (2009, p.218), the Pearson Social Media Survey indicated that the lecturers use social media to some extent in their courses. One may employ social media in a classroom setting in various aspects as explained below. Marquis says that social media is majorly used in the classroom as a channel for communication between the instructor and the student. This is true and the link may be created using Facebook whereby the instructor or lecturer posts course syllabus and assignments and can even take attendance. The World Wide Web complements the lecturers’ information that students get. The internet is where students can get in touch with other learners, experts and experiences in the real world, which an individual teacher may not match. A teacher can provide additional insights by using the web to connect students to others. In addition, the teacher may express alternative points of view via the internet. This is the best way to engage students in a much deeper level with the content of the course. Often, teachers assign students work that require them to research from books and other sources to get the required information. With the internet, students can obtain information at a lower cost with regard to time. They also get information that is up-to-date, and from a wide scope. This is because topics such as education, commerce, religion, politics, or even medicine can be accessed on the internet. Thus, allowing students to access and conduct research through the internet aids their learning. As students conduct research in the internet, they also gain skills on how they too can share their own media or critique work done by others; which helps students to participate in their own knowledge of

Strategic delimma, the quality improvement , equal work load and Case Study

Strategic delimma, the quality improvement , equal work load and quality and patient safety - Case Study Example gaged throughout the project by striving to build trust among team members through team building, strengthening interpersonal relationships and motivating team members by recognizing their contribution to the team (Allio, 2006). I order to get the team underway, Jeff should personally communicate with the expected team members and discuss with them the mission and objectives of the project for them to buy in. After that, he should organize another meeting where they will discuss in detail about the project and progress working on the project with interested members. The committee could have avoided the last minute rush on its project thereby avoiding the conflict on the deadline day of the project. The workload could have been managed easily through cooperation taking in to account the request by one of the team members to be absent for some time at a crucial stage in the project. The committee could work a little bit harder and faster to avoid this scenario. AT the very beginning of the committee’s life, the leader should have come up with a detailed pan on how the workload will be managed. This plan would take in to account significant issues such as the departure by some members at crucial points in the project, including Mariana’s request. The team should include Mariana’s name on the report because of the contribution she has made so far and her desire to do more work to cater for her time off. It was not Marian’s choice to quit the committee at such a point since it was a leadership failure to plan for her absence despite being forewarned. Kyle should reorganize the remaining members in the committee and device a plan for working out the remaining part of the project without Mariana’s contribution. This will facilitate completion of the project within the desired time despite encountering planning problems in the initial strategy of the project. In order to foster strategic thinking in this situation, I will devise an action plan with details

Managing People Global Context-Human Resources Management Essay

Managing People Global Context-Human Resources Management - Essay Example Indeed, it seems that in Starbucks the contribution of employees in organizational performance is highly appreciated. The role of intrinsic and extrinsic motivation in Starbucks is analyzed below using appropriate literature. It is proved that emphasizing on employee motivation can help an organization to increase its competitiveness even when market conditions are quite turbulent, as today. In order to understand the importance of employee motivation for the standardization of business performance, it is necessary to understand the context of employment relationship, as developed in businesses of different size worldwide. According to a description provided by ILO (2005) the employment relationship is a framework in the context of which an individual, called ‘worker’ provides services to the employer, an individual or an organization, under specific terms (ILO 2005, p.22). The terms of the employment relationship, including the level of payment, the length of days-off and so on, can be differentiated in each country according to the local laws and ethics (ILO 2005, p.22). In the literature, the aspects of employment relationship have been extensively explored. Most theorists have focused on the importance of employee satisfaction for employee performance, at the level that an employee who is satisfied with his job he is more likely to perform high compared to an employee who is dissatisfied, i.e. an employee who feels that his contribution in the development of daily organizational activities is not appropriately appreciated (Kaufman 2004). Reference can be made, for example, to the Motivation - Hygiene theory of Herzberg. The specific theory promotes the idea that ‘employee satisfaction and dissatisfaction have two different dimensions’ (Pride et al. 2011, p.283). In fact, the factors that can influence employee satisfaction are divided into two categories, Motivation factors and Hygiene factors.

Advantages and Disadvantages of ESL Course Books Essay Example for Free

Advantages and Disadvantages of ESL Course Books Essay The use of course books in the ESL classroom is very common because the course books have the advantages of being visually appealing, easy for the teacher to prepare, and the activities fits well into the timetable. However, from the researcher’s own teaching experience, there are several problems and issues with the course books such as uninteresting topics, repetitive activities, and not enough language exposure. This in terms may affect the student’s learning attitude and motivation. Overall, using course books has its share of benefits and advantages such as having a well organized content with a consistency in the topics and genres for the four skill area (listening, speaking, reading, and writing). Teachers who adopt a course book may also find it easier to teach since most of the preparation, including the types of activities, audios and in some cases, achievement tests, are already done by the publisher. This would be a great help to those inexperienced teachers who are just getting started into teaching. However, nothing in the world is perfect and teachers need to somehow solve the issues and problems that may come with ESL course books. These issues and problems may include finding ways to motivate students and teaching students academic skills not found in the course books. In this sense, the teacher’s job is not as easy as it seems. Many hours of planning and developing other activities are still required, but these planning and development will benefit both the student and the teacher by making the classroom activities more fun, more interesting, and result in more learning.

Exploring An Occurrence At Owl Creek Bridge

Exploring An Occurrence At Owl Creek Bridge The short story An Occurrence at Owl Creek Bridge has received more critical attention than any other single work written by Ambrose Bierce. This is most likely because of the way the story combines into one text the best components distributed among much of Bierces fiction such as narrative, plot, imagery, the exposure of human-deception, and a surprise ending (Stoicheff 1). In An Occurrence at Owl Creek Bridge, Bierce differentiates between internal and external worlds and illustrates that the mind can create its own realities and escapes. He does not tell the reader that Farquhar is hallucinating, but instead expects the reader to evaluate the story and realize the impossibility of events described in the final events of the story. With such literary techniques, Bierce opposed many of the literary trends of his day in both his journalism and his fiction. He believed any view of life which ignored the unconscious processes of mind could not call itself realistic (Davidson 2). Bierc es works reflect his obsession with ironic, unnecessary, and strange death, as well as his cynical, disillusioned attitude on the meaninglessness of life (Habibi 2). He detested war and saw firsthand the absurdity and insanity of it. This emerges as a connecting theme in several of his writings. His protagonists are usually antiheroes and they make conscious decisions based on flawed thinking, which ultimately lead to tragic predicaments (Habibi 2-3). Bierce is known for his use of literary elements and skillfully uses third person narrative, a quickly paced plot, realistic detail, and blends fantasy and reality to lead the reader into believing in Farquhars escape. Therefore, the reader is unable to interpret Farquhars true fate until the very end of the story. Bierce cleverly chooses to write this story in third person narrative. By using third person narrative, the author is able to do a variety of different things to capture the readers attention and keep them guessing. He most likely chooses this course of action to convey to the reader the main characters feelings and emotions and to conceal his death. This perspective, often called limited omniscience, tells the story from an observers standpoint (Samide 1). By definition, this narrator knows all things important in the story, even a characters own thoughts. Therefore, the reader is able to get a more in depth look into how the main character is feeling, as well as tell the reader the outward world of the story (Samide 1). In this story, the author chooses to focus on the mind of only one main character, Farquhar, and enters it extensively throughout the course of the story. At any given time, the narrator may also move in and out of the chosen characters mind and thoughts, or inform the reader about what is happening in the outer world of the story. Because the author chooses this point of view, it is difficult for the reader to know Farquhars escape is unreal until the last line of the story, when the narrator emerges from his mind to tell the reader Farquhar is dead (Samide 1). Bierce skillfully forces the reader to believe in Farquhars hallucinated escape and therefore, is able to surprise the reader with Farquhars death. It enables Bierce to take the reader inside Farquhars mind to demonstrate how emotional confusion alters not only the way the mind interprets the reality of a situation, but also the way it perceives the passage of time. Bierce also uses a rapidly paced plot to keep the reader from figuring out the surprise ending. He quickly paces the plot in order to distract the reader from closely examining Farquhars unlikely escapes from death. Before the reader has time to consider the likelihood of a broken neck from the rope or some other injury, Bierce has Farquhar struggling not to drown. He sinks deep into the water, his hands still tied together and the noose still wrapped around his neck. So instead of thinking about his broken neck or suffering from another injury, the reader focuses on his new problem of drowning. Then, somehow, Farquhar is able to free his hands from the rope and slips off the noose. But again, the reader is relieved that Farquhar escapes drowning that he does not fully examine the likeliness of this escape. Then, Farquhar bursts to the surface of the water for air and must start dodging bullets, diverting the readers attention once more from the previous escapes from the ropes and dr owning (Samide 3). Therefore, by using a rapid paced plot, Bierce is able to distract the reader from examining the likeliness of the escapes by creating new diversions, making it more believable for the reader. Another literary device Bierce uses in An Occurrence at Owl Creek Bridge is the element of imagery. Bierce relies heavily upon imagery throughout the story, centering on sight and sounds to make his tale more convincing. Bierce goes to great lengths to describe the opening sequence in terms of its military arrangement. He provides vivid images of group formations and soldier stances such as a single company of infantry in line, the barrels inclining backward against the right shoulder, the hands crossed upon the stock, at parade rest the butts of the rifles on the ground (Bierce 72). These descriptions show Bierces past military experience in various wars and battles, giving the story a sense of realism. Also by using such realistic details, Bierce is able to make Farquhars escape more believable to the reader. After the first round of shots from the soldiers, when he hears the captain give orders to fire, Farquhar dives deep into the water. Some of the bullets, still warm from the g uns, spiral down into the water beside him (Samide 3). One lodged between his collar and neck; it was uncomfortably warm and he snatched it out. (Bierce 75) These few examples of realism lead the reader to believe that Farquhar is really escaping. When he comes to the surface again, the current has taken Farquhar out of shooting range of personal weapons, but he must now worry about the cannon being used. The first shot misses, but sprays him with water. The second shot is a much better shot that will surely hit him, but suddenly, the current whirls him around a bend in the river and throws him up on the bank, out of aim of the cannon (Samide 3). While the rapid series of dangers has caused the reader to consider the probability of each escape, the authors use of imagery and realistic detail convinces the reader that he is out of danger and is now on his way to finishing his escape by losing himself in the dense forest and getting back home to his wife and family (Samide 3). The res t of the story goes on to describe Farquhars long trip home. He continues on his journey through the forest and finally arrives to the gate of his own home. He sees his wife and she holds out her hands in joyous welcome. As Farquhar reaches out to embrace her, he feels a stunning blow to his neck, sees a blinding white light, hears a sounds like the shock of a cannon-then all is darkness and silence (Bierce76). At this point in the story, the limited narrator moves out of Farquhars mind and returns to the objective world on the bridge, revealing to the reader the shocking last line and revelation that, all along, the escape was Farquhars hallucination (Samide 3-4). Peyton Farquhar was dead; his body, with a broken neck, swung gently from side to side beneath the timbers of the Owl Creek Bridge. (Bierce 76) One of the literary elements Bierce uses that he is most known for is his blending of fantasy and reality. Bierce mixes the external world of death with Farquhars internal world, resulting in the success of his hallucination. Farquhar, in his mind, is imagining his incredible escape when he is actually dying. Bierce skillfully uses metaphors and similes in order to secretly describe the true fate of Farquhar. For example, Bierce uses the pendulum not only as a significant metaphor for time, but also as a simile for Farquhars body, which swung gently from side to side beneath the timbers of the Owl Creek Bridge (Bierce 76). Farquhar is conscious of motionà ¢Ã¢â€š ¬Ã‚ ¦ of a vast pendulum because his body literally traces, and therefore senses it. Similar intrusions of other objective stimuli into Farquhars experience occur throughout the rest of the story. The sharp report of the firing gun, its slightly later dulled thunder, and the alleged explosion of the cannon that was cracking and smashing the branches in the forest beyond are all Farquhars hallucinated revision of the sound of his own neck breaking. Bierce successfully emphasizes the association, describing the literal event of Farquhars neck breaking as occurring with sound like the shock of a cannon. Farquhars sensation of rising rising toward the surface of the water is the dreamers understanding of the slight bounce the body experiences after reaching the extremity of its flexible rope; the feeling of almost drowning in the creek modifies the fact of strangulation itself; the horribly aching neck and the uncomfortably warm bullet impossibly lodged between his collar and his neck under the water reinterpret the pain of hanging; the counter-swirl that spins him around in the current refers to the twisting at the end of the rope; the projecting point which concealed him from his enemies transforms the bridge now above him; the sensation of his own tongue thrusting forward from between his teeth into the cold air registers its grotesque protrusion during strangulation; the inability to feel the roadway beneath his feet is a similarly accurate feeling, dutifully revised into an understandable fatigue, thirst and numbness near the end of his narrative of escape (Stoicheff 3). Thus, a key element in the story is the distention of time and the blending of fantasy and reality. The reader is left with a range of reactions: the element of surprise, the promise and loss of hope, the tragedy of death, the ultimate coherence of objective reality, and acknowledgment of Bierces carefully constructed deception (Habibi 1). Bierce skillfully blends the third person point of view that conceals Farquhars death until the very end, a rapidly paced plot of narrow escapes from death that distract the reader, concrete details that make the final escape seem real, and the technique of blending fantasy and reality (Samide 4). Bierces usage of narrative, plot, imagery, and blending of fantasy and reality make it hard for the reader to detect Farquhars true fate until the final line of the story. In An Occurrence at Owl Creek Bridge, Bierce distinguishes between the internal and external worlds of Farquhar and shows the reader that the mind can create its own realities and its own escapes. He expects the reader to evaluate the story and realize on his own the impossibility of events described in the final events of the story (Davidson 2). Bierce purposely uses these elements of fiction in order to create a suspenseful ending that connects with the central theme of the human need to escape death. Work Cited Welty Bierce, Ambrose. An Occurrence at Owl Creek. Literature: An Introduction to Reading and Writing. 9th ed. Ed. Edgar V. Roberts. New York: Pearson Longman, 2009, 71-76. Samide, Daniel E. Anatomy of a Classic: Ambrose Bierce Cleverly Used Some Key Literary Tools in Crafting His Civil War Tale An Occurrence at Owl Creek Bridge. The Writer May 2005:42. Literature Resources from Gale. Web. 5 Apr. 2010. Habibi, Don Asher. The experience of a lifetime: philosophical reflections on a narrative device of Ambrose Bierce. Studies in the Humanities 29.2 (2002): 83+. Academic OneFile. Web. 11 Apr. 2010. Davidson, Cathy N. Ambrose (Gwinett) Bierce. American Short-Story Writers Before 1880. Ed. Bobby Ellen Kimbel and William E. Grant. Detroit: Gale Research, 1988. Dictionary of Literary Biography Vol. 74. Literature Resources from Gale. Web. 10 Apr. 2010. Stoicheff, Peter. Something Uncanny: The Dream Structure in Ambrose Bierces An Occurrence at Owl Creek Bridge. Studies in Short Fiction 30.3 (Summer 1993): 349-357. Joseph Palmisano. Vol. 72. Detroit: Gale, 2004. Literature Resources from Gale. Web. 10 Apr. 2010.

Drug Mechanisms and Reactions

Drug Mechanisms and Reactions Phase 1: Drug Metabolism The whole range of biochemical processes that occur within an organism, Metabolism consists both of anabolism and catabolism (the buildup and breakdown of substances, respectively). The biochemical reactions are known as metabolic pathways and involve enzymes that transform one substance into another substance, either breaking down a substance or building a new chemical substance. The term is commonly used to refer specifically to the breakdown of food and its transformation into energy. The liver is the principal site of drug metabolism. Although metabolism typically inactivates drugs, some drug metabolites are pharmacologically active sometimes even more than the parent compound. An inactive or weakly active substance that has an active metabolite is called a pro-drug, especially if designed to deliver the active moiety more effectively. Drugs can be metabolized by oxidation, reduction, hydrolysis, hydration, conjugation, condensation, or isomerization, whatever the process, the goal is to make the drug easier to excrete. The enzymes involved in metabolism are present in many tissues but generally are more concentrated in the liver. Drug metabolism rates vary among patients. Some patients metabolize a drug so rapidly that therapeutically effective blood and tissue concentrations are not reached, in others, metabolism may be so slow that usual doses have toxic effects. Individual drug metabolism rates are influenced by genetic factors, coexisting disorders (particularly chronic liver disorders and advanced heart failure), and drug interactions (especially those involving induction or inhibition of metabolism). For many drugs, metabolism occurs in two phases: Phase I reactions: Which involve formation of a new or modified functional group or cleavage, these reactions are nonsynthetic. Phase II reactions Which involve conjugation with an endogenous substance, these reactions are synthetic. Metabolites formed in synthetic reactions are more polar and more readily excreted by the kidneys (in urine) and the liver (in bile) than those formed in nonsynthetic reactions. Some drugs undergo only phase I or phase II reactions, thus, phase numbers reflect functional rather than sequential classification. Phase I Drug Metabolism Phase I metabolism includes oxidation, reduction, hydrolysis and hydration reactions, as well as other rarer miscellaneous reactions. Oxidations performed by the microsomal, mixed-function oxidase system (cytochrome P450-dependent) is considered separately because of its importance and the diversity of reactions performed by this enzyme system. Classification of Phase I Reactions: Oxidation Reduction Hydrolysis Hydration Dethioacetylation Isomerization Oxidations involving cytochrome P450 (the microsomal mixed-function oxidase) The mixed-function oxidase system found in microsomes (endoplasmic reticulum) of many cells (notably those of liver, kidney, lung and intestine) performs many different functionalisation reactions. CYP 450: The cytochrome P450(CYP) enzyme system consists of a superfamily of hemoproteins that catalyse the oxidative metabolism of a wide variety of exogenous chemicals including drugs, carcinogens, toxins and endogenous compounds such as steroids, fatty acids and prostaglandins. The CYP enzyme family plays an important role in phase-I metabolism of many drugs. The broad range of drugs that undergo CYP mediated oxidative biotransformation is responsible for the large number of clinically significant drug interactions during multiple drug therapy. All of these reactions require the presence of molecular oxygen and NADPH as well as the complete mixed-function oxidase system (cytochrome P450, NADPH-cytochrome P450 reductase and lipid). All reactions involve the initial insertion of a single oxygen atom into the drug molecule. A subsequent rearrangement and/or decomposition of this product may occur, leading to the final products formation. (i) Aromatic hydroxylation: This is a very common reaction for drugs and xenobiotics containing an aromatic ring. In this example the local anaesthetic and antidysrhythmic drug, lignocaine, is converted to its 3-hydroxy derivative. (ii) Aliphatic hydroxylation: Another very common reaction, e.g. pentobarbitone hydroxylated in the pentyl side chain. (iii) Epoxidation: Epoxides are normally unstable intermediates but may be stable enough to be isolated from polycyclic compounds (e.g. the precarcinogenic polycyclic hydrocarbons). Epoxides are substrates of epoxide hydrolase (discussed later), forming dihydrodiols, but they may also spontaneously decompose to form hydroxylated products or quinones. It has been suggested that epoxide formation is the first step in aromatic hydroxylation. (iv) Dealkylation: This reaction occurs very readily with drugs containing a secondary or tertiary amine, an alkoxy group or an alkyl substituted thiol. The alkyl group is lost as the corresponding aldehyde. The reactions are often referred to as N-, O- or S-dealkylations, depending on the type of atom the alkyl group is attached to. (v) Oxidative deamination: Amines containing the structure -CH(CH3)-NH2 are metabolised by the microsomal mixed-function oxidase system to release ammonium ions and leave the corresponding ketone. As with dealkylation, oxidative deamination involves an intermediate hydroxylation step with subsequent decomposition to yield the final products. The product of the oxidative deamination of EPI or NE is 3,4-didydroxyphenylclycoaldehyde (DOPGAL). DOPGAL is subject to reduction to the corresponding alcohol (3,4-dihydroxyphenylethylene glycol, DOPEG) or oxidation to the corresponding carboxylic acid (3,4-dihydroxymandelic acid, DOMA), the latter being the major pathway. (vi) N-oxidation: Hepatic microsomes in the presence of oxygen and NADPH can form N-oxides. These oxidation products may be formed by the mixedfunction oxidase system or by separate flavoprotein N-oxidases. The enzyme involved in N-oxidation depends on the substrate under study. Many different chemical groups can be N-oxidised including amines, amides, imines, hydrazines and heterocyclic compounds. (vii) S-oxidation: Phenothiazines can be converted to their S-oxides (sulfoxides (SÂ ¼O) and sulfones (Â ¼SÂ ¼O)) by the microsomal mixed-function oxidase system. (viii) Phosphothionate oxidation: The replacement of a phosphothionate sulfur atom with oxygen is a reaction common to the phosphothionate insecticides, e.g. parathion. The product paraoxon is a potent anticholinesterase and gives the potent insecticide action as well as the toxicity in humans. Oxidations not catalysed by cytochrome P450 (Non-Microsomal) A number of enzymes in the body not related to cytochrome P450 can oxidize drugs. (i) Alcohol Oxidation by Alcohol dehydrogenase: This enzyme catalyses the oxidation of many alcohols to the corresponding aldehyde and is localised in the soluble fraction of liver, kidney and lung cells. This enzyme uses NAD+ as co-factor and is a true dehydrogenase. (ii) Aldehyde oxidation: Aldehydes can be oxidised by a variety of enzymes involved in intermediary metabolism, e.g. aldehyde dehydrogenase, aldehyde oxidase and xanthine oxidase (the latter two being soluble metalloflavoproteins). (iii) Oxidation by Xanthine oxidase: This enzyme will metabolise xanthine-containing drugs, e.g. caffeine, theophylline and theobromine, and the purine analogues to the corresponding uric acid derivative. Metabolic Reduction (i) Azo- and nitro-reduction can be catalysed by cytochrome P450 (but can also be catalysed by NADPH-cytochrome P450 reductase). (ii) Ring cleavage: Epoxides can be converted back to the parent hydrocarbon, e.g. benzo(a)anthracene- 8,9-epoxide whereas some heterocyclic compounds can be ring cleaved by reduction. (iii) Reductive defluorination: Fluorocarbons of the halothane type can be defluorinated by liver microsomes in anaerobic conditions. Metabolic Hydrolysis Esters, amides, hydrazides and carbamates can readily be hydrolysed by various enzymes. (i) Ester hydrolysis: The hydrolysis of esters can take place in the plasma (nonspecific acetylcholinesterases, pseudocholinesterases and other esterases) or in the liver (specific esterases for particular groups of compounds). Procaine is metabolised by the plasma esterase, whereas pethidine (meperidine) is only metabolised by the liver esterase. (ii) Amide hydrolysis: Amides may be hydrolysed by the plasma esterases (which are so non-specific that they will also hydrolyse amides, although more slowly than the corresponding esters) but are more likely to be hydrolysed by the liver amidases. Ethylglycylxylidide, the N-deethylated phase 1 product of lignocaine, is hydrolysed by the liver microsomal fraction to yield xylidine and ethylglycine. (iii) Hydrazide and carbamate hydrolysis: Less common functional groups in drugs can also be hydrolysed, such as the hydrazide group in isoniazid or the carbamate group in the previously used hypnotic, hedonal. Factors Affecting Metabolism Many factors can affect liver metabolism, such as: In aging, the numbers of hepatocytes and enzyme activity declines. Diseases that reduce hepatic blood flow like heart failure or shock can also reduce the metabolic potential of the liver. Also the use of other drugs as well as dietary and environmental factors can influence liver metabolic function. Metabolism can also be altered due to a genetic deficiency of a particular enzyme. Differences in metabolism that result from functional genetic polymorphisms can be accommodated by knowing the frequency of different genotypes, and by modifying either the enzyme abundance (null alleles, for example, in the case of CYP2D6 poor metabolizers) or the intrinsic enzyme activity (for example, CYP2C9 variants). Data on developmental changes in the abundance and activity of different CYPs can also be incorporated into the models to predict hepatic clearance in neonates, infants and children. Conclusion Metabolism is the breakdown of Drugs inside the body, to disable their activity, forming inactive metabolites, however some drugs are either not affected by metabolism or activated by it, some even form toxic metabolites Examples: Imipiramine not affected by metabolism: Paracetamol produce Toxic Metabolite Metabolism occurs in two phases, Phase I Metabolism, and Phase II Metabolism. Phase I Metabolism converts the drug into metabolite by formation of a new functional group or modifying it, while phase II Metabolism or reactions involve conjugation with indigenous substance. Phase I Reactions Include: Oxidation, reduction, hydrolysis and hydration reactions, and other rare miscellaneous reactions. Oxidation can be divided into Microsomal or non Microsomal according to whether it involves mitochondrial CYP 450 enzymes. Oxidation involves: Microsomal Aromatic Hydroxylation, Aliphatic Hydroxylation, Epoxidation, Dealkylation, oxidative deamination, N- oxidation, S-oxidation and Phosphothionate oxidation. Non-Microsomal Alcohol Oxidation by Alcohol dehydrogenase, Aldehyde Oxidation and Oxidation by Xanthine oxidase. Reduction involves: Azo- and nitro-reduction, Ring cleavage, Reductive defluorination Hydrolysis involves: Ester hydrolysis, Amide hydrolysis, Hydrazide and carbamate hydrolysis

Causing Generation X :: essays research papers

Teenagers wasting 2.3 million dollars worth of gas a year driving around the same block. Kids at the mall for the sole purpose of shop-lifting. Underage consumption parties. Stealing lawn ornaments. These are just some of the effects of Generation X growing up.   Ã‚  Ã‚  Ã‚  Ã‚  The main cause of this destruction of youth is the crumbling of families. No more “Wait until your father gets home from work and ask him'; but “I wonder if we’re going to see a child support check before Christmas.'; With the divorce rate skyrocketing, us kids are feeling more like burdens than blessings. All the problems divorce causes can rip apart a child, and leave him/her craving attention, whether it is negative or positive. To make it worse, while the only parent they live with is working, the two kids turn into a huge group of people decide to make prank phone calls and try beer for the first time. Addictions form and on and on. Pretty soon the kids acting up in class, (more attention, the perfect kind, peer,) getting smashed on the weekends and waking up in someone else’s puke.   Ã‚  Ã‚  Ã‚  Ã‚  Another big reason is boredom. This where my syndrome stems from. There is honestly NOTHING to do in Tuscarwaras County. If you have money in the winter you can bowl, watch a High School basketball game, go to the YMCA, see a movie, go shopping, drive around, experiment with make-up and different types of clothes, get on the Internet, and watch TV. With no money in the winter, we can watch TV, get on the Internet, vandalize, steal , try to bum cigarettes and other such things. The reason the police log is so long every morning is not because kids are heathens, it’s because we are bored. If there was a dance club, a clean place to play pool, an indoor swimming pool , etc., that was free, I guarantee you the problems would clear up. I huge issue that stands out is the whole bike/skateboard thing. Dover/Phila has a huge problem with us riding in town and in allies. I’ve been yelled at hundreds of times “This isn’t a bike park! Get the He*l away form here!'; Well, if they’d build us a place instead of whining about it for months and getting our hopes up then saying no. In order to keep us out of trouble, we need to be occupied with good things It’s not that we don’t want to be.

Purim the Jewish Holiday Essay -- essays research papers

Response Paper Purim Purim is the Jewish holiday commemorating how the Jews of Persia escaped total annihilation thanks to the bravery of Queen Ester. Purim occurs on the 14th of Adar, (or in certain walled cities like Jerusalem, the 15th of Adar.) which this year falls on the 21st of March. The story of Purim is recounted in the Book of Esther, found in the Hebrew Bible. Set in Persia roughly 2,300 years ago, the story tells of how a series of events came together to save the Jewish people from genocide. The Persian empire is taken over by King Achashverosh and to mark the three year anniversary of his reign, Achashverosh throws a huge six-month party. Achashverosh brags that Queen Vashti is the most beautiful woman in the Kingdom, and on the last day of the celebration he summons her to dance for the crowd. Vashti refuses the king's request and the King has her killed. Now Achashverosh needed a new queen and wanted a woman even more beautiful than Vashti, so all throughout Persia officials are appointed to select beautiful candidates to succeed Vashti as queen. In the capital city of Persia, Shushan, a Jewish Orphan by the name of Hadassah lived with her uncle Mordechai. Mordechai was the leader of the Jews, and when Hadassah was selected by the kings officials, Mordechai told her "Don't be afraid. Go with them. Do not tell them you are a Jewess. Tell them your Persian name -- Esther. God will watch over you!? Upon her meeting with the King Ester is appointed Queen and every day Mor dechai stood outside the palace gates, waiting for word from Ester. One day outside the palace, Mordechai over heard two men plotting to kill the king. He warned Esther, who told the King, and the two men were caught and hung. Although it was re... ...seeds. The most popular explanation of why Jews eat this three cornered pastry on Purim is that Haman wore a three-cornered hat and eating an image of Haman?s hat is a way to symbolically destroy his memory. There are four main points to the Purim celebration. First, to read the story of Purim in the evening and the next day, and whenever Haman is mentioned to make as much noise as possible to block out his name and memory. Second, is to send gifts of food to at least one friend or relative, because Purim is a time of love and friendship between Jews. Third, giving gifts of money to the poor because Purim is a time or sharing and helping people. Fourth is the special holiday meal eaten on Purim afternoon, and a little extra point is the dressing up, to celebrate how everything can turn upside-down and into something else, and nothing is exactly what it seems to be.

Biochemistry Fats, Diet, and Heart Disease

Biochemistry Fats, Diet, and Heart Disease ‘Fat’ can sometime be a word that gives people the chills when they hear about it. It is one of the three main sources of calories to our diet and a major part of ones dietary requirement. There are three kinds of fat: saturated, polyunsaturated and monounsaturated. The degree of saturation is dependent on the amount of double and triple bonds in the chemical makeup. Saturated fats are known to increase the body's levels of serum (blood) cholesterol. Along with cholesterol, saturated fats can deposit on the inner walls of blood vessels; a condition known as atherosclerosis.When the heart's arteries become clogged with cholesterol and fats, blood flow can be restricted or totally blocked, leading to severe chest pain and heart attack. Polyunsaturated and monounsaturated fats actually have a cholesterol-lowering effect. By substituting polyunsaturated fats for the saturated fats in your diet, you can actually help control choleste rol levels. Too much dietary fat can also contribute to overweight. Being overweight can aggravate high blood pressure, place excess strain on your heart, and make it more difficult to stay active and physically fit, thus having a negative impact on your overall cardiovascular health.For about three decades, health institutions like the American Heart Association, National Institutes of Health, World Health Organization, and others advised people to reduce dietary fat by limiting fat intake to fewer than 30 percent of daily calories. Their claim was that a low fat diet ultimately resulted in the reduction or elimination of risk for heart disease although; there wasn't much evidence to support the notion of low-fat diets in the beginning.In an article published in the Journal of the American Medical Association on February 8, 2006, in a 8th year Women's Health Initiative Dietary Modification Trial, about 49,000 women with almost identical rates of heart attack, stroke, and other form s of cardiovascular disease were followed to see the effect of a low-fat diet and those not on the diet. Their results showed that women on the low-fat diet didn't lose or gain any more weight than women who followed their usual diets. The important thing to note from these kinds of studies was the type of fat in the diet.For example the Mediterrean style diet is high in fat but these fats are from plant sources such as olive oil, nuts and seeds which are low in saturated fat intake. The ‘Western† diet on the other hand has fats from animal sources which are usually saturated and produces a higher risk for heart disease. In conclusion, as research grows on diet and heart disease, it’s becoming clearer that looking at a single nutrient in isolation cannot tell us the whole story about a person’s heart disease risk. People eat foods, not nutrients, and they eat them in an overall dietary pattern.The traditional Mediterranean Diet pattern, in contrast, appears to lower the risk of heart disease, stroke, and metabolic syndrome, a constellation of factors that increases the chances of developing heart disease and diabetes. So if you are concerned about heart health, pay attention to your overall diet, not just to the type of fat. Citation Barbara, H. (2006) et al. Low-fat dietary pattern and risk of cardiovascular disease. Journal of the American Medical Association. Retrieved from http://jama. ama-assn. org/content/29 5/6/655. full

Informatics In Cancer Prevention Health And Social Care Essay

The purpose, aims, and the of import characteristics of community well-being are good recognized and visibly identified ( Schiavo, 2007 ) chiefly focused on nurturing of the well-being of the community and the populace in general through the activities of bar and control of disease ( Cohen, Chavez and Chehimi, 2010 ) . Soon, public wellness utilizes assorted devices to carry through its intents and due to the epoch of emergent cyberspace rebellion and adept proficient universe, information sciences is an illustration of critical tools that public wellness is using to supply distinguishable and timely attention to the community more proficiently. Supplying such services could be disputing for many grounds due to the fact that when information sciences combines with public wellness services, there are diverse degrees of affairs and issues to be handled ( Yasnoff, O'Carroll, Koo, Linkins and Kilbourne, 1995 ) . In this paper, the advancement made by public wellness over the old ages in relation to malignant neoplastic disease bar through information sciences in the United States will be evaluated. In 1971, there was the realisation that malignant neoplastic disease is a disease that required immediate and pressing attending by the public wellness hence Congress the declared â€Å" war on malignant neoplastic disease, † ( Hess et al. , 2005 p.160 ) . At that clip, it was the apprehension of public wellness that covering with malignant neoplastic disease was like managing a solo disease. Surprisingly, it did non take much clip for public wellness suppliers to come to the realisation that malignant neoplastic disease is a terrifying, hard, and a disease with many causes and beginnings that requires immediate full public consciousness and actions. Shortly, after this realisation, the conflict against malignant neoplastic disease became one of the precedences of the twenty-first century ; â€Å" a war to be fought on multiple foreparts against a diffuse enemy and for which bar was the most wise way to triumph † ( Hess et al. , 2005 p. 159 ) . In order to win and win t his battle against malignant neoplastic disease, the National Cancer Institute ( NCI ) needed to integrate the rules of wellness information sciences in guaranting that the populace is empowered through an environment that is supportive and which integrates information sciences, transforms scientific discipline, delivers safe and patient-oriented wellness attention, with accent on single control, in public wellness. To accomplish these ends, Hesse ( 2005 ) indicated that NCI connotations include the use of three assorted wellness information sciences applications: â€Å" applications in bioinformatics, applications in medical information sciences and applications in consumer information sciences † ( p. 159 ) . This information sciences would take the way of systematic engineering invention, enhances the handiness of an environment that supports protected and efficient health care bringing, and empowers persons to take charge of their personal wellness severally. Taking charge of one ‘s wellness includes bar of diseases such as malignant neoplastic disease and direction of any disease in the event that such disease was non evitable. To maintain these applications on path, wellness attention decision makers must take a sociotechnical attack to execution. The new systems must be built into the wellness attention environment in such a manner that they support human capacities, provide failsafe backups in the face of cognitive and physical restrictions, and support uninterrupted quality betterment. In July 2001 the Institute of Medicine released â€Å" Traversing the Quality Chasm, † its landmark prescription for wellness attention in the twenty-first Century. The major subject of the study was far making: â€Å" Health attention today is characterized by more to cognize, more to pull off, more to watch, more to make, and more people involved in making it than at any clip in the state ‘s history. † No one person can anticipate to hold on the complexness of modern medical scientific discipline, nor can any one person stay abreast of the tsunami of informations and findings that comprise effectual wellness attention over the life span of a typical patient ( IOM, 2001 ) . Changes must be made, writers of the study argued, to the really system in which wellness attention occurs to cover with the sheer volume of mounting medical information, and to guarantee that the right information is brought to bear at the right clip on every wellness determination made throu ghout an person ‘s lifetime. The lone manner to maintain up with alterations and demands of the populace is through progresss in information engineering. At the really least, the wellness attention system has to be redesigned to do the same indispensable usage of information technology-through computerized records direction, electronic informations interchange, and safety systems-that are already standard in other industries ( UDDHHS, 2004 ; Daniel, 2006 ) . More critically, to win the wellness conflicts of the twenty-first century, the system will necessitate to do substantial springs frontward. It must turn to suit an information rich environment of wellness attention that is supportive of wellness and health in the twenty-first century. In this paper, the author will explicate how the battle against malignant neoplastic disease is conceptualized by research workers and practicians at the National Cancer Institute ( NCI ) , the establishment that is tasked by the US Federal Government to take research attempts against the disease. Then followed by explicating how the development of a co-ordinated public wellness information sciences substructure will be a necessary, enabling measure for transforming the research endeavor, bettering pattern, and enabling personal wellness decision-making. In 1971, with the transition of the Cancer Act, the U.S. Congress declared â€Å" war on malignant neoplastic disease † ( Congress, 1971 ) , and since so attempts have been to towards remedy. The scientific advancement made since that clip has been amazing, but what the biomedical community learned was merely how formidable and sophisticated the enemy was. What we now know to be malignant neoplastic disease is truly a household of 100 + diseases, each with parallel yet distinguishable aetiologic waies, and a deadly inclination to engender new malignances through an insidious procedure of metastasis. Rather than resemble the â€Å" Great War † against a individual enemy, the war on malignant neoplastic disease looks more like the twenty-first century â€Å" war on panic † – a drawn-out conflict that requires a high degree of intelligence and monitoring to debar menace wholly or observe and extinguish menace early earlier harm becomes widespread. Understanding the pathology of malignant neoplastic disease provides an enlightened position of where the Windowss of chance are for commanding the disease. For illustration through the attempts of public wellness run against the usage of baccy led to the first important decrease in deceases due to malignant neoplastic disease in the twentieth century ( Von Eschenbach, 2005 ) . Besides, malignant neoplastic disease showing has been credited with dramatically cut downing mortality from cervical malignant neoplastic disease and decreases in mortality are being achieved through early sensing of chest, prostate, and colorectal malignant neoplastic diseases ( National Academy of Sciences, 2012 ) .If testing helps the control of malignant neoplastic disease it is alluring to explicate a policy that would recommend for wide spectrum showing processs routinely for the bulk of the population. It does non take long, nevertheless, to calculate out that the disbursal of such an attack, non to ad vert the undue breaks from false positives for those non at hazard, would be prohibitory. Another nutrient for idea is, if so many malignant neoplastic diseases are evitable through primary and secondary bar schemes, and the function of the human genome is unlocking the secrets of more effectual showing trials, so why has malignant neoplastic disease eclipsed bosom disease as a figure 1 slayer of Americans aged 85 old ages and younger? One of the replies may be that our ability to bring forth informations may hold outstripped our ability to use and incorporate new cognition. Journalist David Schenk referred to this as â€Å" Data Smog, † a status that exists when excessively much natural information precipitates â€Å" palsy by analysis † among scientists, and excessively many intelligence narratives depicting the latest â€Å" scientific determination † leave consumers bewildered and bedraggled ( Shenk,1997 ) . The thought of public overload became evident by replies to the National Cancer Institute ‘s ( NCI ) Health Information National Trends Survey ( HINTS ) in 2003. HINTS is a two-year, random digit dial telephone study designed to measure grownups ‘ use of different communicating media and their resulting cognition, attitudes, and behaviours relevant to malignant neoplastic disease control ( Nelson et al. , 2004 ) . In the study respondents were asked on a one to five scale how much they agreed with the statement that â€Å" there are so many different recommendations it is difficult to cognize what to make to forestall malignant neoplastic disease. † About 75 % of the sample indicated they â€Å" strongly agreed † or â€Å" agreed † with the statement that there were excessively many recommendations to cognize what to make ( Hesse, et al. , 2005 ) . To accomplish advancement in malignant neoplastic disease bar, it is of import that healthcare forces maintain up with the many new engineerings, incorporating them into the crowded work flow of a patient centered medical pattern. Integration a nd application will be indispensable if malignant neoplastic disease research workers wish to travel invention into pattern and to hold an impact on the national malignant neoplastic disease load. The solution rests in tackling the power of health-related information sciences. The Gallic term â€Å" informatique † was coined in the early 1960 ‘s to depict an emerging engineering that would let scientists to pass on informations via computing machine webs. Heavy investing in the 1960 ‘s and 1970 ‘s in the United States led to the development of a robust web protocol ( Transmission Control Protocol – Internet Protocol ) that would construct on the information sciences construct by enabling defence research workers and contractors to pass on informations with each other over widely distributed and loosely interconnected computing machine webs. Further investings in the U.S. during the 1980 ‘s and 1990 ‘s enabled the National Science Foundation to widen the benefits of information sciences substructures to basic scientific discipline research workers and to pedagogues. That period culminated in the development of the NSF high velocity anchor, a public substructure designed to enable high velocity transmittal of infor mations and messages across the US and to selected research labs internationally. Further force per unit area on the US Congress led to the formation of programs to enable a wide information sciences substructure for public usage, which led to a denationalization of a national information sciences substructure ( NII ) and an credence of TCP-IP as the criterion for inter-network connectivity. On November 15, 2001 the U.S. Department of Health and Human Services ( DHHS ) published a study by the National Committee on Vital and Health Statistics naming for the development of a National Health Information Infrastructure, or NHII ( National Committee on Health and Vital Statistics, 2001 ) . To spread out entree to the information, and to salvage clip and disbursal from reinventing the same computing machine resources across research labs, the NCI has invested in a common information sciences substructure caBIG ( for the malignant neoplastic disease Bio-Informatics Grid ) , this substructure will function as a common information platform through which take parting labs may portion protocols, metadata ( i.e. , informations about informations ) , contacts, computing machine applications, vocabularies, depository informations, and instruments which is regarded as collaboratory ( Buetow, 2005 ) . Another end of engineering is to enable a new epoch of scientific discipline in which research workers and clinicians, from different parts of the state and from entirely different subjects, can unite forces. Therefore, the engineerings must be able to back up an epoch of large-scale â€Å" squad scientific discipline † ( IOM, 2003 ) . An illustration is the Cancer Molecular Assessment Project, or caMAP. The primary end of the caMAP undertaking is to ease the designation of molecular marks for malignant neoplastic disease. This is achieved by utilizing genomic informations onto the web at the NCI. The information will so be combined with information on molecular tracts obtained from BioCarta, a functional categorization of cistrons. Connections to molecularly targeted curative agent information are made through the NCI ‘s Cancer Therapy Evaluation Program. The concatenation of patterned advance in the function of public wellness information sciences for malignant neoplastic disease bar includes the grounds garnered from biomedical scientific discipline and direct nexus with wellness attention bringing system in seasonably, safe, and effectual ways. Unquestionably, information engineering must play a important function in conveying the right information, into the right relationship, at the right clip to take full advantage of Windowss of chance in malignant neoplastic disease attention. There are by and large four types of computing machine applications that have been developed over the past two decennaries that can ease the find to bringing procedure. They include: ( a ) interoperable and interrelated records direction systems, ( B ) bibliographic hunt and retrieval systems, ( degree Celsius ) determination support systems, and ( vitamin D ) biomedical imaging systems. The end of making a truly interoperable and interrelated electronic medical record system has been more elusive. In malignant neoplastic disease attention, the promise of developing portable electronic wellness record systems will enable new chances for intercession across the full malignant neoplastic disease attention continuum. Cancer patients are particularly at hazard as they transition from one wellness attention puting to another, and as they transfer attention from general practicians to medical oncologists. An interrelated medical record system, if executed right, will make a better occupati on at back uping these passages. The public-service corporation of bibliographic databases will enable doctors throughout the universe unparalleled entree to the medical literature. Future attempts will needfully concentrate on making newer and more efficient seeking algorithms to assist oncologists convey the best grounds to bear on every determination they make, irrespective of how rare the malignant neoplastic disease is. On-line information science tools, such as the Cancer Control Planet for public wellness decision makers will give determination shapers vetted entree to evidence-based plans as contained within the medical and public wellness literature. Another computing machine application is the Decision support systems ( DSS ) . Since the early 1970s, determination support systems ( DSS ) engineering and applications have evolved significantly. Many technological and organisational developments have exerted an impact on this development. DSS one time utilized more limited d atabase, mold, and user interface functionality, but technological inventions have enabled far more powerful DSS functionality. DSS one time supported single decision-makers, but subsequently DSS engineerings were applied to workgroups or squads, particularly practical squads. The coming of the Web has enabled inter-organizational determination support systems, and has given rise to legion new applications of bing engineering every bit good as many new determination support technologies themselves. Mobile tools, nomadic e-services, and wireless Internet protocols are taging the following major set of developments in DSS. In the early history of public wellness information sciences, the populace did non swear computing machines for determination devising. They were non willing to release personal control over decision-making as a consequence of the determination procedure non been clear to them. Computers will non be able to replace higher degrees of thought and judgement but has bee n able to execute some of the boring undertakings associated with information direction. Their true part is in supplying human decision-makers with better quality information so that they can do better determinations. To utilize Zuboff ‘s footings, computing machines will non â€Å" automate ; † they will â€Å" informate † ( Zuboff, 1984 ) . As a consequence, it is critical for public suppliers to cognize that the best usage of engineerings is non to replace clinical judgement, but to augment it. Public wellness information sciences continues to play important function in health care and engineerings provide a assortment of chances to turn to public wellness challenges such as malignant neoplastic disease. Datas from the 2003 disposal of the Health Information National Trends Survey revealed that the public relied on the cyberspace as their first beginning of information on malignant neoplastic disease bar ( Hesse et al. , 2005 ) . This determination is consistent with on-line wellness information tendencies reported from other studies. In tracking the figure of Americans traveling online, the U.S. Census Bureau noted a gradual slope from â€Å" 22.2 % in 1997 to 42 % in 2000 and 51 % in 2001. By 2003, the HINTS information placed the figure of Americans online at 63.0 % ( 95 % CI, 61.7-64.3 ) † . Of those who report being online, â€Å" 63.7 % ( 95 % CI, 61.7-65.8 ) † reported holding looked for medical information for themselves or for others sometime in the old 12 months. Sing what sort of wellness information people search for online, Rice reported that â€Å" malignant neoplastic disease † was the 3rd most popular health-related hunt term on the Web after â€Å" depression † ( # 1 ) and â€Å" allergic reactions † ( # 2 ) ( Rice, 2001 ) . Each twenty-four hours the figure continues to increase and public wellness information sciences continues to hold consequence in malig nant neoplastic disease bar. This is an of import ground for Consumer Informatics which require multiple channels. To back up information seeking in complex environments, Marchionini ( 1995 ) , the National Cancer Institute ( NCI ) continues on the betterment of scientific guidelines and to the full equipped serviceability research lab to carry on research and rating. NCI was instrumental in piecing an grounds base for the design of wellness related Web sites. NCI has intensified in its attempts to better public wellness consciousness in the bar of malignant neoplastic disease through public wellness information sciences. For illustration, the diffusion of Personal Health Records online, allows patients to supervise their ain electronic medical information. This promotes a greater sense of self-advocacy among patients, thereby doing them more argus-eyed in supervising their ain wellness conditions and can go more proactive in modulating their ain wellness behaviours an of import par t of public wellness information sciences in malignant neoplastic disease bar. ( ? Reference ) . Besides, reminder systems embedded within the personal wellness record can motivate patients to see their doctors for everyday showing trials or can supply instructions for behaviour when research lab values exceed safe scopes. In kernel, the patient can go portion of the wellness attention squad, supervising his or her ain wellness in more informed ways. Greater support for self-care, both for persons and their health professionals is an of import facet of public wellness particularly as chronic diseases continue to lift. An addition in edification within on-line media is merely one aspect of a to the full supportive and healthy environment. Other media – newspapers, magazines, telecasting, wireless, and booklets will prevail as new communicating channels come online. In general, the new mix of media will look more disconnected and specialized than the early yearss of mass commun icating. The new mix will besides be more synergistic than the predating information environment and will be fueled by an implicit in convergence of engineerings. In the early yearss of the Internet wellness communicators thought of the World Wide Web as a concluding finish for wellness information searchers. The accent was making content to be browsed on screen in Hyper Text Markup Language ( HTML ) . Using the Web as a bringing mechanism, instead than a finish, could intend supplying Web surfboarders with downloadable, printer-friendly booklets that could easy be circulated to others. By back uping meeting engineerings, wellness information Web interior decorators could widen their public wellness range beyond the Digital Divide. Public wellness Informaticians must acknowledge that wellness attention environments are made up of people, tools, and conversations. Redesign attempts must maintain this in head if the attempts are to be successful ; new engineerings must be compatible with user properties and they must be supportive of work flow and communicating demands. Understanding and placing the audience is a cardinal point for presenting any public wellness intercession, it is indispensable to cognize the targeted audience, wellness literacy degree, readability degree, therefore the wellness communicating manner, format, and linguistic communication will be good received, accepted, and understood by that peculiar audience. Since every public wellness communicating has a intent and say to bring forth an result from the targeted audience, it is required that it will utilize the recognized tools that helps to actuate this audience to lend to the result effectual of communicating ( Schiavo, 2007 ) . As a consequ ence, Schiavo entreaties to public wellness professionals on this point and says that – it is of import to retrieve that public wellness communicating starts and ends with the audience ( Schiavo, 2007 ) . O'Carroll et Al. ( 2003 ) besides warns public wellness information sciences professionals and partisans and say that success of public wellness information sciences is non merely about computing machines and hardware but it is about the people who will utilize and implement these systems and webs because public wellness information sciences creates value. The attacks used by public wellness forces yielded and continues to bring forth positive result on malignant neoplastic disease bar. This shows that credence of a public wellness message depends on how it is presented ( Schiavo, 2007 ) . The first point to see when implementing a new engineering is to understand exhaustively the work environment into which the engineering will be integrated. Many Health IT undertakings fai l when deployed in existent universe scenes. These are scenes filled with conflicting work demands, clip restraints, and into which foisting a hard-to-use or error-prone computing machine system would bring mayhem. As the engineering of medical scientific discipline becomes more complex, the grade of hazard associated with utilizing the engineering additions. So excessively, the demand arises to guarantee that the engineerings are embedded within the environment of medical attention in a seamless, effectual, and safe manner. This exhortation was a nucleus subject in the Institute of Medicine ‘s comrade studies to the medical community: â€Å" To Err is Human and Traversing the Quality Chasm † ( Institute of Medicine, 2000 ) . An expressed subject of the book was that mistakes do non stand for failures of persons, but failures of the wellness attention system and the mode in which attention is delivered. To better bringing techniques, mistakes must be addressed from a sy stemic and a human factors perspective. In working with human capacities, instead than against them, systems applied scientists must concentrate on constructing the back-ups and failsafe processs into their engineerings that allow worlds to run within natural tolerances for cognitive capacity and physical restrictions. Because discrepancies are natural, the system must besides be self-correcting. It should be infused with informations supervising systems that can inform uninterrupted quality betterment, and it should do careful usage of intelligent agents to inform -not take away from – human judgement and decision-making. Another country in which systems applied scientists and wellness attention forces are concentrating on in order to better the function of wellness information sciences in the bar of chronic diseases for illustration malignant neoplastic disease is in supplying degrees of support that go beyond individual minutess which Zuboff and Maxmin ( 2002 ) referred to as the construct of supplying â€Å" deep support † Supplying deep support entails trust-filled relationship between wellness attention system and their client. In the Web economic system, developers have frequently made the unforesightful error of seeking to pull out concern value from each and every dealing through the add-on of â€Å" start up ads † † ( Zuboff & A ; Maxmin, 2002 ) into the user ‘s attending, frequently while the clients were seeking to happen critical information. When a end directed visitant comes to a Web site looking for of import wellness information, the last thing they want is to be bombarded with a bombardment of targeted advertizements or to pick up on a wellness message that is uncomplete, disconnected, or filled with uninterpretable words. Where information sciences systems need to travel following is to associate all facets of a patient ‘s information environment together to organize an unbroken cradle of â€Å" deep support † over clip. The Institute of Medicine referred to this end as making a â€Å" healing relationship † with the wellness attention system, in which some facet of a coordinated attention environment can be made available in patient-centric ways 24 hours a twenty-four hours, 7 yearss a hebdomad. It is the long-run support facet of wellness attention bringing coordinated across people and systems that will turn the tide on malignant neoplastic disease. As promotion in health care continues through information sciences, links must be drawn to the single patient, to be certain that the patient is supported over a life-time of wellness information decision-making. Making an environment that is every bit supportive of all members of the population is critical. Serviceability interior decorators refer to this construct as Universal Design ( Deering, 2002 ) . Universal Design construct allows characteristics in the environment that will let for maximal inclusion across changing degrees of physical ability and across scopes of socioeconomic strata in the community. For illustration, Curb cuts which are indentures built into pavements that give people in wheelchairs easy entree to the food market shops, office edifices, and promenades and which are besides utile to people who are physically able, as they can be used as waies for shopping carts, babe saunterers, bags on â€Å" wheelies, † and bikes. The characteristic is a cosmopolitan design, since it benefits everyone. This same construct is an illustration of public wellness function in the betterment of wellness via information sciences ( Shneiderman, 1998 ) because attempts are made to construct kerb cuts into comput ing machines. An illustration is the ability to set ocular position or â€Å" rapid climb † in graphical user interfaces. Size accommodations do it easy for people with differing degrees of ocular sharp-sightedness to set the size of objects on the screen ( say words or Numberss ) for easiness of sing. Another manner of nearing cosmopolitan design is to make systems that adapt easy to differing degrees of experience or proficient edification ( Shneiderman, 1998 ) Staging a web site so that information of cosmopolitan involvement is contained within the first few beds, while supplying well-marked waies to the more sophisticated proficient information is of import for the bar of chronic diseases such as malignant neoplastic disease. Attention to rules of cosmopolitan design in malignant neoplastic disease attention will make an intelligent wellness attention environment that, like a well-marked main road, will take all users down the route to malignant neoplastic disease free lives. The findings of the function of public wellness information sciences in malignant neoplastic disease bar and control provide possible waies for concentrating preventative intercessions. More research is needed to better understand how wellness information can be used more widely and efficaciously. One country of research could analyze how organisations obtain and utilize this information ; what value users derive from the information ; which types of flexible tools users would happen most utile ; and preparation and other capacity demands needed to promote the effectual usage of the information. It is believed that the new and evolving subject of public wellness information sciences is the key to consistently and scientifically worki ng this chance to the benefit of the populace ‘s wellness. This demand is an chance and challenge for me as a public wellness information sciences pupil to carry on farther research that will turn to public wellness information sciences issues with cognition gained from this class and plan. To reason, it has been over three decennaries since Congress foremost declared war on malignant neoplastic disease and public wellness attempts in anti-smoking runs has decreased the rate of lung malignant neoplastic disease in work forces, with similar lessenings in adult females non far behind. Successful usage of early sensing plans in chest and cervical malignant neoplastic disease, prostate malignant neoplastic disease, and colorectal malignant neoplastic disease have cut back rates of mortality on each of those foreparts. Coincidentally, the new war on malignant neoplastic disease is being fought with engineering ; information sciences calculating. To reason, there is a new mentality to malignant neoplastic disease bar because public wellness information sciences is communicated in a manner that creates value in the mark population. The NCI continues to make a hereafter in which persons are empowered with the information and tools they need to take cancer-free lives and one in which decease and enduring from malignant neoplastic disease will be nonexistent through public wellness information sciences, bioinformatics, medical information sciences, and consumer information sciences. Regardless of these and such hurdlings, Centers for Diseases Control has shown pronounced advancement ( CDC 2011a-b, CDC, 2010 & A ; O'Carroll, 2003 ) in the usage and application of engineering to public wellness in public wellness information sciences both at federal and local degrees. Harmonizing to CD ‘s Public Health Information Network ( PHIN ) , the end is besides to make populations at planetary degree.